Up to 1877, paralysis as a predominant feature of rabies was not distinguished. It was recognized that paralysis might sometimes appear as a terminal condition, but always following, it was thought, the usual hydrophobic symptoms. Bruardel's1 description is typical of that time: "In man rabies passes through three stages; the first is characterized by melancholy; the second by excitement and spasms of the organs of respiration and deglutition; the third, of short duration, which is rarely reached by the patient, is characterized by paralysis."
Gamaleia2 in 1877, in a study of twenty cases of rabies in which paralysis was the predominant symptom, endeavored to distinguish on this basis a paralytic form of the disease differing from the usual type, in which paralysis occurred not at all or only as a terminal event. He grouped his cases according to the mode of onset of the paralysis. In some cases
KNUTTI RE. ACUTE ASCENDING PARALYSIS AND MYELITIS DUE TO THE VIRUS OF RABIES. JAMA. 1929;93(10):754–758. doi:10.1001/jama.1929.02710100016007
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