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August 28, 2018

Medications for Alcohol Use Disorder and Predicting Severe Withdrawal

Author Affiliations
  • 1Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts
  • 2Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts
  • 3Grayken Center for Addiction, Boston Medical Center, Boston, Massachusetts
  • 4Associate Editor, JAMA
JAMA. 2018;320(8):766-768. doi:10.1001/jama.2018.10061

Robust validated prediction rules tested in randomized trials guide clinical decisions that reduce risk for major cardiovascular events, breast cancer, and numerous other conditions. With more than 2.4 million hospital discharges of patients with alcohol use disorder (AUD) per year in the United States,1 and after almost 70 years of research, clinicians might expect that the same prediction rules would exist to predict severe withdrawal. But these rules are not available.