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JAMA Clinical Guidelines Synopsis
September 11, 2018

Diagnosis and Treatment of Clostridium difficile Infection

Author Affiliations
  • 1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
  • 2Department of Internal Medicine, University of Chicago, Chicago, Illinois
  • 3Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
JAMA. 2018;320(10):1031-1032. doi:10.1001/jama.2018.12194

Clostridium difficile is a common health care–associated infection in the United States with an increasing incidence of community-acquired disease that can be very severe and has a significant risk of mortality. Recurrent CDI is increasing disproportionately to primary CDI.1 Management of CDI is determined by disease severity, history of CDI, and a patient’s risk of recurrence.2

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