To the Editor Changing the P value threshold to .005 does not solve the issue of how to interpret P values.1 It simply shifts the burden of proof to require a more extreme difference.
Uncertainty regarding the potential benefit of a therapy that demonstrated a clinically meaningful but now statistically nonsignificant result would increase.2 The demonstration of the reproducibility of experiments, a cornerstone of the scientific method, would be diminished and restricted to those therapies showing large differences (together with large sample sizes). Clinicians may feel abandoned.
Gebski V, Byth K. Lowering the P Value Threshold. JAMA. 2018;320(9):935–936. doi:10.1001/jama.2018.8729
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