To the Editor The Viewpoint by Dr Ioannidis discussed the recent proposal by a coalition of 72 methodologists to lower the statistical significance threshold to .005.1,2 Ioannidis acknowledged limitations of this proposal; however, his Viewpoint did not discuss any financial implications of this change.1 Powering randomized clinical trials (RCTs) and prospective observational studies at an α level of .005 would translate into considerably higher costs associated with larger sample sizes.
Hernandez I, Gellad WF, Good CB. Lowering the P Value Threshold. JAMA. 2018;320(9):935. doi:10.1001/jama.2018.8733
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