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Encephalitis occurring after vaccination against smallpox has been rarely observed in France—much less often than in the more northern regions of Europe, and especially in the Netherlands. M. Netter, the French physician who has studied this question most in France, discussed the subject recently before the Academy of Medicine. He thinks that the conception of certain authors according to which a virus existed previously in the brain of the subjects and was enhanced in virulence by the vaccine, and likewise the assumption that the vaccine was contaminated or that there was an epidemic of encephalitis, should be abandoned. He contends that it is a question of an attack on the brain by the vaccinal virus itself, which can occur only in subjects with a nervous system that is particularly susceptible and with a very active vaccine. He recommends, with the present vaccines, to make only one vaccinal insertion
PARIS. JAMA. 1929;93(11):858–859. doi:10.1001/jama.1929.02710110044018
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