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September 9, 1944


Author Affiliations

U. S. Public Health Service STATEN ISLAND, N. Y.

From the Venereal Disease Research Laboratory and the United States Marine Hospital.

JAMA. 1944;126(2):63-67. doi:10.1001/jama.1944.02850370001001

In a preliminary report1 the influence of penicillin therapy on the clinical manifestations and serologic reactions of patients with early syphilis was presented. The report was based on the results of a curtailed period of observation of a group of 4 patients. It is our purpose in the present paper to record the findings of post-treatment observation of the original group for periods in excess of three hundred days. It is also desired to record certain items of information which have resulted from the treatment of an additional 100 patients.

REVIEW OF ORIGINAL GROUP  Of the group of 4 patients the records of whom formed the basis for the preliminary report,1 all have been maintained under observation. It will be recalled that these patients displayed dark field positive lesions of early syphilis at the time of treatment. The therapy consisted of an intramuscular injection of 25,000 units of