Youth with disruptive behavior disorders who were treated with antipsychotic medications for the first time had increases in body fat and decreases in insulin sensitivity over 12 weeks, found a trial published in JAMA Psychiatry.
More than half of the 144 antipsychotic-naive youths aged 6 to 18 years in the study had a primary diagnosis of attention-deficit/hyperactivity disorder (ADHD) that did not respond to prior therapy. Participants were randomized to receive oral aripiprazole, olanzapine, or risperidone for 12 weeks.
Slomski A. Antipsychotics May Affect Metabolism. JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13871
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