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Clinical Trials Update
September 25, 2018

Antipsychotics May Affect Metabolism

JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13871

Youth with disruptive behavior disorders who were treated with antipsychotic medications for the first time had increases in body fat and decreases in insulin sensitivity over 12 weeks, found a trial published in JAMA Psychiatry.

More than half of the 144 antipsychotic-naive youths aged 6 to 18 years in the study had a primary diagnosis of attention-deficit/hyperactivity disorder (ADHD) that did not respond to prior therapy. Participants were randomized to receive oral aripiprazole, olanzapine, or risperidone for 12 weeks.