The complexities of social identity and genetic ancestry have led to confusion and consternation related to the use and interpretation of race, ethnicity, and ancestry data in biomedical research. These discussions and overt debates have intensified with advances in genomics and knowledge about how social factors interact with biology. As more information about genomic diversity becomes available, the limitations of assigning social, political, and geographic labels to individuals become clearer; these limitations have led to growing challenges for researchers to communicate information about human genomic variation.