Tissue repair following a wound occurs along a spectrum ranging from underhealing, as occurs in chronic wounds, to overhealing, as is seen in fibrosis.1 In the United States, it is estimated that as many as 4.5 million people have chronic wounds, resulting in substantial economic and psychosocial costs. Various pathologic states result in chronic wound development, including arterial or venous insufficiency, diabetes, undue skin pressure, presence of a foreign body, and infection.2
Jones RE, Foster DS, Longaker MT. Management of Chronic Wounds—2018. JAMA. 2018;320(14):1481–1482. doi:10.1001/jama.2018.12426
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