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October 2, 2018

Gut Microbes May Account for the Anti-Seizure Effects of the Ketogenic Diet

JAMA. 2018;320(13):1307. doi:10.1001/jama.2017.12865

The low-carbohydrate, high-fat ketogenic diet is an effective treatment for many patients who have epilepsy that fails to respond to existing anticonvulsant medications, but the detailed mechanisms behind the diet’s beneficial effects on brain activity and behavior remains to be fully elucidated. New research published in Cell points to a pivotal role for the gut microbiome in mediating the effects of the diet.