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September 23, 1944

METABOLIC CRANIOPATHYA CLINICAL AND ROENTGENOLOGIC STUDY OF SO-CALLED HYPEROSTOSIS FRONTALIS INTERNA

JAMA. 1944;126(4):213-217. doi:10.1001/jama.1944.02850390011004
Abstract

Metabolic craniopathy has been defined as "a syndrome characterized clinically by variable and protean manifestations of a metabolic, endocrine and neuropsychiatric nature and roentgenologically by characteristic thickening of the internal tables of the skull."1 The condition has been commonly referred to as hyperostosis frontalis interna, but this is a less suitable designation since the changes observed in the skull do not appear to contribute to the clinical picture nor are they probably an essential part of the syndrome. The changes in the skull are moreover not always limited to the frontal bones, and hence the designation metabolic craniopathy would appear preferable. Other designations which have been used for certain forms of this disorder are the eponyms Morgagni's and Stewart-Morel's syndrome and the terms "cranial hyperostosis of the insane" and "calvarial hyperostosis." These too fit the condition less satisfactorily, however, than does the designation metabolic craniopathy.

Although metabolic craniopathy is

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