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September 30, 1944

CURRENT STATUS OF PROPHYLAXIS BY HEMOPHILUS PERTUSSIS VACCINE

JAMA. 1944;126(5):294-299. doi:10.1001/jama.1944.82850400002008
Abstract

In 1914 the Council on Pharmacy and Chemistry of the American Medical Association admitted pertussis vaccines to New and Nonofficial Remedies on the basis of what appeared at that time to be acceptable clinical evidence. During the next fifteen years these vaccines were used extensively for both prophylaxis and treatment. The reports, however, indicated that the results were not very satisfactory. Therefore in 1928 the Council voted to omit pertussis vaccines from New and Nonofficial Remedies with the close of the longest period for which any one had been accepted, unless new evidence proving efficacy was produced. Reports from different investigators continued to vary and in 1931 the Council1 recommended that these vaccines be entirely omitted from New and Nonofficial Remedies.

It is interesting to note that in the same year one of the most important advances in the study of the pertussis organism was made. Leslie and Gardner

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