In Reply Dr Gao and colleagues comment that supplementary data tables1 suggest that the separation in achieved 25(OH)D concentrations were greatest at the 3-month adjusted age follow-up visit, and that the differences in wheezing episodes were short-lived. Although a decrease in the separation of 25(OH)D concentrations over time likely arises from the study design, we do not think that the data support a conclusion that the benefit of the sustained supplementation strategy was evident only in the first 3 months of life.
Hibbs AM, Wagner CL, Tatsuoka C. Vitamin D Supplementation in Young Infants and Recurrent Wheezing—Reply. JAMA. 2018;320(16):1708–1709. doi:10.1001/jama.2018.11537
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