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Article
October 12, 1929

Das Exsiccoseproblem.

JAMA. 1929;93(15):1171. doi:10.1001/jama.1929.02710150063030

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Abstract

This concise monograph is an experimental study of exsiccosis, which is referred to in the American literature as anhydremia (dehydration). The latter terms, according to Schiff, do not exactly indicate the process which he believes takes place. Consequently he instituted a series of experiments in which he attempted to produce exsiccosis and to present a more precise understanding of the underlying biochemical processes. The author gives credit to his teacher Czerny for first calling attention to the physiology and pathology of water metabolism of the growing infant. Schiff limited the water intake to one half or less of the normally required amount. The remainder of the diet was quantitatively and qualitatively unaltered. The food administered was principally cow's milk, and he employed a powdered dry milk because he felt that in this way he could obtain standard solutions. In the infant, Schiff noticed that, when exsiccosis occurred, restlessness, apathy and

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