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Comment & Response
November 6, 2018

Stress-Related Disorders and Autoimmune Disease

Author Affiliations
  • 1Department of Child Psychiatry, Shenzhen Kangning Hospital, Shenzhen, China
  • 2Mental Health Institute, The Second Xiangya Hospital, Changsha, China
JAMA. 2018;320(17):1816-1817. doi:10.1001/jama.2018.12394

To the Editor Dr Song and colleagues1 reported that stress-related disorders were associated with increased risk of subsequent autoimmune disease. Stress is an adverse event that is associated with various mental disorders and physical diseases, possibly through hypothalamic-pituitary-adrenal axis dysregulation, epigenetic modification, or the inflammatory response.2,3 The study presented several problems that require further discussion.