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JAMA Diagnostic Test Interpretation
October 31, 2018

Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis

Author Affiliations
  • 1Division of Gastroenterology, Duke University Health System, Durham, North Carolina
  • 2Duke Clinical Research Institute, Durham, North Carolina
  • 3Durham Veterans Affairs Medical Center, Durham, North Carolina
JAMA. 2018;320(19):2031-2032. doi:10.1001/jama.2018.13073

A 68-year-old man was diagnosed with chronic hepatitis C genotype 1b 5 years ago. He had no evidence of advanced liver disease (eg, thrombocytopenia). Liver ultrasound showed no signs of cirrhosis, such as nodularity. Vibration-controlled transient elastography (VCTE) performed prior to treatment was negative for signficant fibrosis at 6.7 kPa. Hepatitis C was cured, based on viral load, with simeprevir and sofosbuvir for 12 weeks. He presents for follow-up. Laboratory studies and VCTE were performed (Table 1).

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