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Comment & Response
November 13, 2018

Guidelines on Glycemic Targets for Persons With Type 2 Diabetes—Reply

Author Affiliations
  • 1Chicago Center for Diabetes Translation Research, University of Chicago, Chicago, Illinois
JAMA. 2018;320(18):1937-1938. doi:10.1001/jama.2018.13421

In Reply We agree that the ACP guidance statement has ignited critical dialogue and attention to an important issue. Our rating for “establishing evidence foundations” was largely based on the lack of justification for including only the 5 long-term randomized trials referenced in existing guidelines.1 Prioritization of trial data over other data are part of a larger debate about the quality of evidence required to make clinical decisions. Although we agree that trial data, when available, should be considered more heavily, it is impossible for trial data to exist for every important clinical question. Thus, other sources of evidence can be informative for making clinical recommendations.