Madeline Lancaster, PhD, started her postdoctoral work in 2010 with plans to investigate the basic mechanisms of neurogensis using 2-dimensional (2D) cell culture methods. But a happy accident set her off on another path.
“I made some mistakes and I ended up not being able to get my cells to stick to the [culture] dishes,” she recalled. “[T]hese cells floated off and formed these three-dimensional aggregates that then started to take on really interesting morphologies and started to generate neurons.”
Sancar F. For Difficult-to-Model Brain Diseases, Brain Organoids Come to the Rescue. JAMA. 2018;320(19):1966–1968. doi:10.1001/jama.2018.15972
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