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November 18, 1944


JAMA. 1944;126(12):737-740. doi:10.1001/jama.1944.02850470001001

The term perlèche, until recently employed solely in the vocabulary of dermatology, has assumed popular proportions, it now being used rather freely by general physicians, pediatricians, internists, dentists and other practitioners. Likewise, equally or more popular, since the work of Sebrell and Butler,1 followed by others, has become the diagnosis ariboflavinosis and cheilosis, the latter term having been coined by the original investigators to denote the commissural and other lip manifestations of that disease. Most writers, in describing the changes at the angles of the mouth in vitamin B complex deficiency, have captioned it "perlèche," though some have referred to it as "perlèche-like" involvement. Who of us has not seen many a patient of late who has been treated unsuccessfully by his pediatrician or general physician or dentist for fissuring of the oral commissures by administration of riboflavin, the treatment having been prescribed in the absence of other signs

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