To the Editor Dr Rudd and colleagues1 concluded that the quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score was superior to the systemic inflammatory response syndrome (SIRS) score and a baseline risk model in predicting in-hospital mortality in low- and middle-income countries (LMICs), an issue that has been debated since its introduction in the Sepsis-3 definitions.2,3 We are concerned that the treatment of missing data may have introduced significant bias.
Lewis JM, Henrion M, Rylance J. Validity of the qSOFA Score in Low- and Middle-Income Countries. JAMA. 2018;320(19):2038–2039. doi:10.1001/jama.2018.14473
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