High-dose folic acid supplements taken after the first trimester of pregnancy did not prevent preeclampsia in high-risk women according to a trial published by the BMJ.
The trial enrolled 2301 women who were 8 to 16 weeks pregnant and had at least one risk factor for preeclampsia (preexisting hypertension, prepregnancy diabetes, twin pregnancy, prior preeclampsia, or a body mass index of ≥35). Participants received either daily high-dose (4 mg) folic acid or placebo until delivery. All participants could continue taking up to 1.1 mg of folic acid throughout pregnancy.
Slomski A. High-Dose Folic Acid Does Not Prevent Preeclampsia. JAMA. 2018;320(20):2068. doi:10.1001/jama.2018.18511
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