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Comment & Response
December 4, 2018

Sepsis Bundles and Mortality Among Pediatric Patients

Author Affiliations
  • 1Children’s Hospital Colorado, Aurora
  • 2Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  • 3Advocate Children’s Hospital, Oak Lawn, Illinois
JAMA. 2018;320(21):2271. doi:10.1001/jama.2018.16748

To the Editor Dr Evans and colleagues demonstrated that delivery of bundled care within 1 hour was associated with a significant reduction in pediatric sepsis mortality in 59 hospitals in New York State, although individual bundle elements were not.1 Prior pediatric studies have similarly shown that timely bundled sepsis care was associated with improved outcomes, despite differences in bundle components and population.2-4 These studies together suggest that delivery of locally defined best care, including timely fluid and antibiotics, improves outcomes, even when bundle details differ.