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Comment & Response
December 4, 2018

Acupuncture for Aromatase Inhibitor–Related Joint Pain Among Breast Cancer Patients

Author Affiliations
  • 1Columbia University Medical Center, New York, New York
  • 2Fred Hutchinson Cancer Research Center, Seattle, Washington
JAMA. 2018;320(21):2270-2271. doi:10.1001/jama.2018.16744

In Reply As Drs Mao and Farrar point out, based on current guidelines, clinical trials reporting pain should report the proportion of patients with a clinical response (either a 2-point change on an 11-point scale or a 30% reduction). Our study1 was designed to detect a 2-point difference between groups. We based this on the study by Farrar et al,2 although we recognize now that their study did not actually define what a clinically meaningful difference between groups is. As we stated in the discussion, several recent randomized studies of pain control interventions have reported clinically meaningful between-group mean differences ranging from 0.7 to 1.0 points.3,4 Our results fell within this range.