In Reply As Drs Mao and Farrar point out, based on current guidelines, clinical trials reporting pain should report the proportion of patients with a clinical response (either a 2-point change on an 11-point scale or a 30% reduction). Our study1 was designed to detect a 2-point difference between groups. We based this on the study by Farrar et al,2 although we recognize now that their study did not actually define what a clinically meaningful difference between groups is. As we stated in the discussion, several recent randomized studies of pain control interventions have reported clinically meaningful between-group mean differences ranging from 0.7 to 1.0 points.3,4 Our results fell within this range.
Hershman DL, Unger JM, Crew K. Acupuncture for Aromatase Inhibitor–Related Joint Pain Among Breast Cancer Patients. JAMA. 2018;320(21):2270–2271. doi:10.1001/jama.2018.16744
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