In Reply Dr Scott and colleagues discuss the contribution of the New York pediatric sepsis mandate analysis1 to prior literature and highlight challenges to the study of time-sensitive sepsis bundles in children. We agree that there is heterogeneity of sepsis cases and criteria for treatment across New York hospitals. We were encouraged that our findings were consistent after extensive adjustment for measured confounders in multiple sensitivity analyses. We also agree that consensus definitions for pediatric sepsis and time to treatment will allow for more efficient study of existing and new quality improvement and policy initiatives in sepsis.
Evans IVR, Angus DC, Seymour CW. Sepsis Bundles and Mortality Among Pediatric Patients—Reply. JAMA. 2018;320(21):2271–2272. doi:10.1001/jama.2018.16751
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