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JAMA Diagnostic Test Interpretation
December 25, 2018

The Direct Antiglobulin Test for Evaluating Anemia

Author Affiliations
  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
  • 2The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland
JAMA. 2018;320(24):2593-2594. doi:10.1001/jama.2018.14317

A 68-year-old woman with Rai stage 0 chronic lymphocytic leukemia (CLL) presented with a 2-day history of dyspnea on exertion. She reported no cough, chest pain, orthopnea, leg swelling, or viral-like symptoms. Her temperature was 36.8°C, heart rate 102/min, respiratory rate 22/min, and blood pressure 124/76 mm Hg. She had conjunctival pallor and scleral icterus, but no lymphadenopathy, hepatosplenomegaly, or ecchymosis. Results of initial laboratory testing are presented in the Table.