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Clinical Trials Update
December 25, 2018

Chemoimmunotherapy for Triple-Negative Breast Cancer

JAMA. 2018;320(24):2521. doi:10.1001/jama.2018.20159

A chemoimmunotherapy combination with the programmed death ligand 1 (PD-L1) inhibitor atezolizumab prolonged progression-free survival in women with metastatic triple-negative breast cancer, an aggressive cancer with poor outcomes, according to a trial in the New England Journal of Medicine.

The 902 women with untreated metastatic triple-negative breast cancer were randomly assigned to receive atezolizumab plus nanoparticle albumin-bound (nab)–paclitaxel, or placebo plus nab-paclitaxel. Participants continued the regimen until their cancer progressed or adverse effects became too toxic.