In 2013, Science named cancer immunotherapy its Breakthrough of the Year, and in 2018, the Nobel Prize in Physiology or Medicine was awarded to the 2 researchers who helped established this paradigm-shifting approach to cancer treatment.
James Allison, PhD, of MD Anderson Cancer Center and Tasuku Honjo, PhD, of Kyoto University, Japan, shared the prize for elucidating 2 different immune checkpoint pathways that put the brakes on CD8+ T cells, dampening their killer instincts and preventing them from destroying cancerous cells.
Friedrich M. Immunotherapy 2.0: Improving the Response to Checkpoint Inhibitors. JAMA. 2019;321(2):131–133. doi:10.1001/jama.2018.18306
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