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From The Medical Letter on Drugs and Therapeutics
January 1/8, 2019

Hydrogen Peroxide 40% (Eskata) for Seborrheic Keratoses

JAMA. 2019;321(1):99-100. doi:10.1001/jama.2018.16100

The FDA has approved hydrogen peroxide 40% topical solution (Eskata – Aclaris Therapeutics) for treatment of raised seborrheic keratoses (SKs) in adults. It is the first drug to be approved for this indication. (Hydrogen peroxide is available over the counter for topical use as a 3% solution.)

SKs are benign, usually pigmented skin growths with a wart-like appearance that occur in about 83 million people in the US, primarily middle-aged and older adults.1 They generally do not require treatment, but patients may want them removed for cosmetic reasons or because they have become irritated.2 Cryotherapy with liquid nitrogen is the most common method for removing SKs. It can cause mild pain, scarring, and hyper- or hypopigmentation (pigmentary changes are more common in patients with dark skin). Curettage, shave excision, electrocautery, and laser treatment are also used to remove SKs.