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January 22, 2019

Aspirin for Primary Prevention: Clinical Considerations in 2019

Author Affiliations
  • 1VA Boston Healthcare System, Jamaica Plain, Massachusetts
  • 2Division of Aging, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
JAMA. 2019;321(3):253-255. doi:10.1001/jama.2018.20577

Reducing platelet activity with aspirin and other antiplatelet agents is an important factor in the prevention and management of atherothrombotic vascular events.1 For this indication, aspirin has both beneficial and potentially harmful effects; it can diminish or reverse thrombus formation (eg, in the setting of acute myocardial infarction or stroke), but it also increases the risk of bleeding.