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Clinical Trials Update
January 29, 2019

Novel Antibiotic Efficacious in Treating Gonorrhea

JAMA. 2019;321(4):335. doi:10.1001/jama.2018.22029

Oral zoliflodacin, an antibiotic that inhibits microbial biosynthesis, effectively treated most cases of uncomplicated urogenital and rectal gonococcal infections, according to a phase 2 trial in the New England Journal of Medicine.

Men and women who had symptoms or untreated urogenital gonorrhea or who had sex in the preceding 2 weeks with a partner with gonorrhea were randomly assigned to receive a single oral dose of zoliflodacin (2 g or 3 g) or to a single 500-mg intramuscular dose of ceftriaxone.

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