In a 2018 study published in JAMA Network Open, Silverstein et al1 used mediation analysis to investigate how a problem-solving educational program prevented depressive symptoms in low-income mothers. Using data from a randomized trial, the authors tested 8 plausible mechanisms by which the intervention could have its effects. They concluded that problem-solving education reduced the risk of depressive symptoms in low-income mothers primarily by reducing maternal stress.
Lee H, Herbert RD, McAuley JH. Mediation Analysis. JAMA. 2019;321(7):697–698. doi:10.1001/jama.2018.21973
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