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Comment & Response
February 5, 2019

Treatment of Recurrent Clostridium difficile Infection—Reply

Author Affiliations
  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
  • 2Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
  • 3Department of Internal Medicine, University of Chicago, Chicago, Illinois
JAMA. 2019;321(5):513. doi:10.1001/jama.2018.19004

In Reply We believe that the recent IDSA/SHEA guidelines on diagnosis and treatment of CDI are a significant update and provide treating clinicians with tools to better diagnose and manage CDI.1 There have been some important changes from earlier guidelines. We agree that the recommendations for treatment of recurrent CDI with either a tapered and pulsed vancomycin regimen, a standard fidaxomicin regimen, or a vancomycin regimen are based on weak data, as this particular question has not been studied systematically.1