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January 13, 1945

BILATERAL ORCHIECTOMY FOR CARCINOMA OF THE PROSTATE GLAND: CLINICAL EXPERIENCE

JAMA. 1945;127(2):63-67. doi:10.1001/jama.1945.02860020007003
Abstract

The investigations of Huggins and his associates concerning castration in cases of carcinoma of the prostate gland have been stimulating. The time now has come for members of the medical profession to report their experiences with the procedure in order to assist in its final evaluation as treatment. Although more time is needed to follow patients before all questions can be answered finally, preliminary reports seem justifiable and may be helpful. For this reason we are submitting our experience at the Mayo Clinic up to the present date.

DATA CONCERNING ALL PATIENTS WHO UNDERWENT BILATERAL ORCHIECTOMY FOR CARCINOMA OF THE PROSTATE GLAND  This report deals with 220 patients who received a clinical diagnosis of carcinoma of the prostate gland and who underwent bilateral orchiectomy at the clinic from June 1, 1941 to Dec. 31, 1943 inclusive. Of these patients 62 have returned one or more times since orchiectomy for examination. Information concerning the remainder has been sought by letters of inquiry. We have up to date information on 215 of these patients, and it is on this number that this report will be based. The diagnosis has not been proved by microscopic examination of prostatic tissue in all of these cases, because

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