For the study of the ultimate results of any surgical procedure a thorough knowledge of the disease for which the operation is performed is essential, especially the course of the particular disease when uninfluenced by treatment. In any pathologic process there are numerous variables encountered, and in no type of disease is this so true as in cancer. Great variations occur in the rapidity of growth of the original neoplasm as the result of differences in the biologic activity of the individual cells as well as their tendency to invade the lymphatics or the blood stream. It is obvious, therefore, that only by a detailed study of long series of cases can a true picture of the disease be obtained, so that when a diagnosis of this particular disease has once been made the physician is able to prognosticate with a reasonable degree of accuracy the course which the disease
COLSTON JAC. SURGICAL REMOVAL OF CANCER OF THE PROSTATE GLAND: THE RADICAL OPERATION. JAMA. 1945;127(2):69–74. doi:10.1001/jama.1945.02860020013005
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