The absorption and distribution of penicillin in the various body fluids after parenteral injection and the duration of its survival in body fluids or cavities under normal and pathologic conditions are questions of considerable interest in penicillin therapy. Although some studies have been made in certain cases, there has apparently been no method for penicillin titer of such body fluids easily applicable to routine observations in clinical cases. In this paper we report the results of observations made on penicillin levels in the blood serum and other body fluids by the use of a relatively simple method which has yielded apparently consistent results and some useful information. The patients studied were for the most part infants and children in the St. Louis Children's Hospital who were receiving penicillin therapy and in addition a few adults from the medical service of Barnes Hospital on whom observations were made through the kindness
COOKE JV, GOLDRING D. THE CONCENTRATION OF PENICILLIN IN VARIOUS BODY FLUIDS DURING PENICILLIN THERAPY. JAMA. 1945;127(2):80–87. doi:10.1001/jama.1945.02860020024008
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