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January 20, 1945

THE PREVENTION AND ATTENUATION OF INFECTIOUS HEPATITIS BY GAMMA GLOBULIN: PRELIMINARY NOTE

JAMA. 1945;127(3):144-145. doi:10.1001/jama.1945.02860030016004
Abstract

Infectious hepatitis (epidemic hepatitis, infective hepatitis) has been stated to be one of the most important diseases of the present war.1 It has also been a serious problem in civilian populations throughout the world. Owing primarily to the lack of knowledge concerning the etiologic agent and its mode of transmission, adequate methods of prevention and control have not as yet been developed. It is our purpose in this preliminary report to present data which suggest that gamma globulin2 from large pools of adult human serum may be effective in the control of certain epidemics of this disease.

Parenteral injections of homologous blood products (whole blood, pooled plasma or serum, pooled measles and mumps convalescent plasma, and so on) have occasionally been followed by hepatitis. These blood products have usually been derived from single individuals or, in the case of pools, from relatively small numbers of young adults. The

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