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February 15, 2019

Enterovirus D68–Associated Acute Flaccid Myelitis: Rising to the Clinical and Research Challenges

Author Affiliations
  • 1Hospital Medicine and Pediatric Infectious Disease Sections, Department of Pediatrics, University of Colorado, Aurora
  • 2Children’s Hospital Colorado, Aurora
  • 3Neuroinfectious Disease Section, Department of Neurology, University of Colorado, Aurora
  • 4Departments of Medicine and Immunology-Microbiology, University of Colorado, Aurora
JAMA. 2019;321(9):831-832. doi:10.1001/jama.2019.1016

In the summer of 2014, the emergence of an upsurge in cases of a poliomyelitis-like paralytic syndrome in the United States, designated acute flaccid myelitis (AFM), generated substantial concern among the medical community and the public. There were 120 confirmed AFM cases in 34 states in the summer and fall of 2014. In 2016, this increased to 149 cases in 39 states, and in 2018 there were at least 210 confirmed cases from 40 states (as of February 10, 2019).1 These numbers compare to a likely baseline incidence of 22 to 35 cases per year scattered throughout the intervening years of 2015 and 2017.1

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