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Comment & Response
February 26, 2019

Thyroid Hormone Therapy for Subclinical Hypothyroidism

Author Affiliations
  • 1Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, England
  • 2Rotterdam Thyroid Centre, Erasmus Medical Centre, Rotterdam, the Netherlands
JAMA. 2019;321(8):804. doi:10.1001/jama.2018.20002

To the Editor Dr Feller and colleagues reported a systematic review and meta-analysis of randomized clinical trials (RCTs) assessing the relationship between thyroid hormone therapy and quality of life (QOL) and thyroid-related symptoms in patients with subclinical hypothyroidism.1 We have several concerns regarding the conclusions concerning the lack of evidence for benefit of thyroid hormone therapy in adults with subclinical hypothyroidism.