To the Editor Dr Feller and colleagues reported a systematic review and meta-analysis of randomized clinical trials (RCTs) assessing the relationship between thyroid hormone therapy and quality of life (QOL) and thyroid-related symptoms in patients with subclinical hypothyroidism.1 We have several concerns regarding the conclusions concerning the lack of evidence for benefit of thyroid hormone therapy in adults with subclinical hypothyroidism.
Razvi S, Peeters R, Pearce SHS. Thyroid Hormone Therapy for Subclinical Hypothyroidism. JAMA. 2019;321(8):804. doi:10.1001/jama.2018.20002
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