In previous studies1 of salts of penicillin, which included the sodium, lithium, ammonium, strontium, calcium, magnesium and potassium salts,2 it was demonstrated that under the proper conditions of test all seven salts were equally efficacious in the treatment of pneumococcic infections in mice. It was shown also that the toxicity of these preparations in these animals was dependent on the cation used in their production.
In the present study each salt of penicillin was assayed chemically to determine the weight of cation present, and in no case was the amount in 100,000 units sufficient to contraindicate its use in man.
Thirty-five patients with sulfonamide resistant gonorrhea were treated with the seven salts of penicillin, 5 patients with each preparation. In the group were 23 females, 8 white and 15 colored, and 12 males, all colored. Their ages varied from 14 to 44. All patients in this series were
PUTNAM LE, WELCH H, OLANSKY S. TREATMENT OF GONORRHEA AND STUDIES OF INTRAMUSCULAR IRRITATION: WITH SEVEN SALTS OF PENICILLIN. JAMA. 1945;127(4):204–205. doi:10.1001/jama.1945.02860040014003
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