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January 27, 1945


JAMA. 1945;127(4):244. doi:10.1001/jama.1945.02860040054019

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To the Editor:—  Introduction of new chemical agents for clinical use involves a serious responsibility and requires the utmost care in skilful execution and interpretation of laboratory findings and sound judgment in evaluation of clinical results, as emphasized years ago (The Journal, Nov. 23, 1929, p. 1632). Both laboratory and clinical studies must conform to the best accepted standards for the specific types of experiments involved. The desirability of setting up a universally standard scheme of appraisal, such as that authorized "as a pattern" by the Council on Pharmacy and Chemistry in The Journal, Dec. 9, 1944, page 958, may nevertheless be questioned. Aside from differences of opinion regarding the most valid technics for particular phases of a standardized appraisal, it is doubted that standardization of the experimental background for new drugs should be as detailed as that recommended.Ultimately the value of any chemical agent in treatment depends on

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