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February 3, 1945

THE TREATMENT OF PNEUMOCOCCIC MENINGITIS WITH PENICILLIN

JAMA. 1945;127(5):263-267. doi:10.1001/jama.1945.02860050011003
Abstract

Pneumococcic meningitis remains as one of the acute infections most difficult to treat successfully. Before the introduction of the sulfonamides it was almost invariably fatal. Even with the very vigorous use of sulfonamides and type specific serums the results have been far from satisfactory. The case fatality rate has been reported to vary from 58 per cent1 to 80 or 90 per cent,2 depending on the type of case received in the institution in which the study was made. Since pneumococci are highly sensitive to small amounts of penicillin, and since this agent is very effective in pneumococcic pneumonia,3 much can be expected from its employment in pneumococcic meningitis.2

Our purpose in the present report is to detail our experience with the use of penicillin in the treatment of 16 patients with pneumococcic meningitis and to compare the results with those obtained in 40 consecutive patients

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