The production of carcinoma of the thyroid in rats1 is of extraordinary interest to all students of carcinogenesis and of thyroid disease. Wilson, De Eds and Cox2 at Stanford University discovered that 2-acet-aminofluorene fed to rats produced neoplasm of many organs and tissues. Bielschowsky,3 working in Great Britain, confirmed their observations that the implanted substance did not cause local inflammation or new growths, while feeding caused cancers of the external auditory canal, the lungs, salivary glands, liver, pancreas, bladder and breast as well as leukemias and sarcomas. All this occurred in a species with a low spontaneous occurrence of tumors and from an agent that does not cause cirrhosis or other degenerative changes. Obviously a carcinogen of extraordinary potency has been discovered by the American pathologists. None of the cancerous animals in either series had tumors of the thyroid gland. Nor did cancers occur in rats fed
THIOUREA AND EXPERIMENTAL CARCINOGENESIS IN THE THYROID. JAMA. 1945;127(5):278–279. doi:10.1001/jama.1945.02860050026010
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