Among the gram negative bacteria, Neisseria intracellularis appears to be particularly sensitive to the sulfonamides. In active cases of epidemic meningitis the numerous organisms in the blood, spinal fluid and nasopharynx fortunately disappear rapidly as soon as therapy is instituted. In my experience the nasopharyngeal cultures usually are negative twenty-four hours after the administration of sulfadiazine either orally or intravenously.
The remarkable effect of sulfadiazine on N. intracellularis has been utilized by giving prophylactically two or more doses of 2 Gm. to contacts of active cases and to inductees beginning basic training. In the spring of 1943 the administration of 2 Gm. of sulfadiazine daily for two days to 700 men resulted in substantial reduction in the number of cases of meningococcic meningitis during an epidemic period.1 The result had been a striking check of the spread of meningitis by the elimination of most of the carriers and a
PILOT I. SENSITIVENESS OF MENINGOCOCCI TO THE SULFONAMIDES: RAPID EFFECT OF ADMINISTRATION OF TWO GRAMS OF SULFADIAZINE ON CARRIERS OF NEISSERIA INTRACELLULARIS (MENINGOCOCCUS). JAMA. 1945;127(6):310–311. doi:10.1001/jama.1945.02860060008003
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