Areas of necrosis involving the epiphyses and also the primary centers of ossification in certain of the short bones have been described by different observers. Unfortunately in most instances the lesion has come to be known by the name of the original observer. This has the disadvantage of giving no hint as to the underlying pathologic process and, further, of implying that in each instance we are dealing with an independent disease which bears no relation to the others in the series. These diseases have been known also under more general headings such as epiphysitis, osteochondritis and subchondral necrosis. It is now generally accepted that they all represent the same underlying pathologic process, although there is no general agreement as to the exact etiologic agent.
Several theories have been advanced to explain the occurrence of areas of necrosis in the short bones and epiphyses. Endocrine dysfunction has been suggested.
DOUB HP. ASEPTIC NECROSIS OF THE EPIPHYSES AND SHORT BONES: ROENTGEN STUDIES. JAMA. 1945;127(6):311–317. doi:10.1001/jama.1945.02860060009004
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