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Comment & Response
March 19, 2019

Challenges in Research on Suicide Prevention

Author Affiliations
  • 1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston
  • 2Department of Psychiatry, Henry Ford Health System, Detroit, Michigan
  • 3Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas
JAMA. 2019;321(11):1105. doi:10.1001/jama.2018.21951

To the Editor Drs Sisti and Joffe1 described challenges in conducting research on suicide. We agree that such research should include individuals with suicidal behavior and that suicide attempts and death are appropriate outcomes for trials. We also agree that conceptualizing the outcome of suicide as an adverse event might trigger objections by regulatory bodies that jeopardize the feasibility of such investigations.