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February 10, 1945

TREATMENT OF STAPHYLOCOCCIC, PNEUMOCOCCIC, GONOCOCCIC AND OTHER INFECTIONSWITH PENICILLIN

JAMA. 1945;127(6):325-329. doi:10.1001/jama.1945.02860060023007
Abstract

GONOCOCCIC INFECTIONS  Table 3 records the results of the penicillin treatment of 12 female patients with sulfonamide resistant gonorrhea, and 1 male patient with sulfonamide resistant gonococcic prostatitis and epididymitis. Before being given penicillin each of the female patients in this series was subjected to an intensive course of sulfadiazine therapy during which the blood concentration of the drug was maintained at a level of 7 to 20 mg. per hundred cubic centimeters. Only after the sulfonamide therapy had failed to cure the infection was penicillin treatment instituted. In all but 2 cases a total dosage of only 75,000 units or less was employed. All but 1 of the 12 female patients were followed in the hospital for a period of thirty days after treatment.11 During this period only one questionable relapse was observed. The following case report illustrates the effectiveness of penicillin in the treatment of acute peritonitis

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