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Comment & Response
March 26, 2019

Adverse Events Associated With Immune Checkpoint Inhibitors

Author Affiliations
  • 1Barbara Davis Center for Diabetes, University of Colorado, Aurora
JAMA. 2019;321(12):1219. doi:10.1001/jama.2018.22119

To the Editor Dr Johnson and colleagues1 summarized the adverse events associated with immune checkpoint inhibitor therapy used to manage advanced cancers, which predominantly respond to treatment with glucocorticoids. However, we want to emphasize an irreversible adverse effect, autoimmune diabetes, which can present with life-threatening diabetic ketoacidosis and permanent insulin deficiency.