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Clinical Trials Update
March 26, 2019

Compounded Pain Creams Offer No Benefit

JAMA. 2019;321(12):1149. doi:10.1001/jama.2019.2496

Compounded pain creams were no more effective than placebo creams for localized chronic pain, according to a study in Annals of Internal Medicine.

The 399 pain patients—more than 40% active-duty military personnel—were divided into 3 subgroups based on their localized pain type: neuropathic, nociceptive, or mixed. Participants in each group were randomly assigned to receive a specially formulated compounded pain cream appropriate for their pain type or a placebo cream.