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February 10, 1945


JAMA. 1945;127(6):353. doi:10.1001/jama.1945.02860060051020

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To the Editor:—  The communication of Chauncey D. Leake and his associates (The Journal, January 27, p. 244) discussing our recent article "The Laboratory and Clinical Appraisal of New Drugs" (The Journal, Dec. 9, 1944, p. 958) deserves comment, since there are some real differences of opinion regarding some of our proposals. Our paper was concerned not only with setting forth technics to be used in the investigation of new drugs but also with the establishment of criteria whereby laboratory and clinical data can be evaluated. We included suggestions regarding the type of study which in our opinion would be productive of useful information. As we indicated, however, these suggestions are by no means exhaustive. We pointed out, as has Professor Leake, that selection of suitable experimental animals is a very important consideration in the laboratory evaluation of new agents. Professor Leake has emphasized the importance of a study of

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